Comment on the apoE4 gene in case it intrigues you.
I don’t think any gene survived because it increases a bad outcome. I think we agree it would be the opposite. I think the issue in research that many don’t think about is that our genes are a mismatch to our modern environment.
The E4 gene was probably helpful in the past. I believe it is more a problem today for those who live an inflammatory lifestyle especially as it relates to a high processed food high carbohydrate high Omega 6 fat diet.
Cholesterol is not evil no matter what the establishment believes. So producing more is a factor of what our body needs to deal with our daily environment.
Absolutely. There are so many examples of variants that are common in our genome because they gave some kind of advantage that allowed our ancestors to survive and reproduce. Most examples that I know of are related to immune response and surviving a pathogen, which always made me wonder if the links between amyloid beta and viral pathogens in the brain are key to the prevalence of APOE E4.
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The ApoE4 may have be a benefit in terms of surviving infections, hence the increase in both Beta-Amyloid and lipids in brain and coronary vasculature. They are there to fix a problem, not cause it.
But our diet/lifestyle is so inflammatory that it is now a mismatch for our genes, and E4's end up with higher rates of vascular issues, BUT I believe primarily due to the inflammatory diet.
Debbie
Luv your work.
Comment on the apoE4 gene in case it intrigues you.
I don’t think any gene survived because it increases a bad outcome. I think we agree it would be the opposite. I think the issue in research that many don’t think about is that our genes are a mismatch to our modern environment.
The E4 gene was probably helpful in the past. I believe it is more a problem today for those who live an inflammatory lifestyle especially as it relates to a high processed food high carbohydrate high Omega 6 fat diet.
Cholesterol is not evil no matter what the establishment believes. So producing more is a factor of what our body needs to deal with our daily environment.
Thoroughly enjoy your work!
Absolutely. There are so many examples of variants that are common in our genome because they gave some kind of advantage that allowed our ancestors to survive and reproduce. Most examples that I know of are related to immune response and surviving a pathogen, which always made me wonder if the links between amyloid beta and viral pathogens in the brain are key to the prevalence of APOE E4.
Thanks so much for commenting! I didn't realize you had a substack newsletter -- signing up for it now.
The ApoE4 may have be a benefit in terms of surviving infections, hence the increase in both Beta-Amyloid and lipids in brain and coronary vasculature. They are there to fix a problem, not cause it.
But our diet/lifestyle is so inflammatory that it is now a mismatch for our genes, and E4's end up with higher rates of vascular issues, BUT I believe primarily due to the inflammatory diet.