Hot Flashes, Genetics, and Natural Solutions
What works, what's new in the research
Hi everyone,
This week's new article on hot flashes was a frequently requested topic by members. As I read through the research, it was interesting to see how genome-wide association studies have led to new solutions for hot flashes.
About a decade ago, researchers found that genetic variants in a neuropeptide called neurokinin 3 were associated with hot flashes. This led to drug development, clinical trials, and FDA approval of a neurokinin 3 drug this year.
It was interesting to read the research on natural supplements for hot flashes. Some that are often promoted for hormone-related problems showed little efficacy, while others that I would never have associated with hot flashes, such as saffron, may actually work.
Gratefully yours,
~ Debbie
Hot flashes, genetics, and natural solutions
Key takeaways:
~ Up to 80% of women will experience hot flashes, or vasomotor symptoms (VMS), during menopause.
~ Research shows that changes in estrogen levels and activation of neurokinin 3 receptors in the hypothalamus are involved in triggering hot flashes.
~ Natural supplements and key lifestyle changes may help to reduce the intensity and duration of hot flashes.
What causes hot flashes?
Have you ever experienced a sudden wave of heat during menopause? You’re not alone. About 53-80% of women experience hot flashes around the time of menopause.[ref]
Hot flashes, or vasomotor symptoms, are a hallmark of the menopausal journey for many women. Hot flashes cause a sudden feeling of warmth, often accompanied by sweating and a flushed face. Some people also feel irritable and anxious during a hot flash. At night, hot flashes can cause night sweats and disrupt sleep.[ref]
What causes hot flashes? Why does the body’s temperature system seem to suddenly go haywire? Let’s dive into the science...
What I've been reading:
1. FDA panel says common over-the-counter decongestant doesn’t work
This NBC news report explains that the FDA has decided that phenylephrine doesn't work as a decongestant. This is a common OTC decongestant that is the most common oral decongestant sold in the US.
A 2007 meta-analysis of 8 different studies came to the same conclusion, as did other studies over the past decade. Why did it take so long for the FDA to weigh in? I don't know. However, this is a good reminder that looking at the research studies on a medication may give insight into whether it actually works or not.
2. Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
The study - in mice - caught my eye for the interaction with the gut microbiome.
From the study: "NMN also increased the relative abundance of short-chain fatty acids (SCFAs)-producing bacteria such as Lactobacillus and Bacteroides at the genus level by protecting intestinal health and improving AD."
Read more about NMN, NR, and NAD+